Bruker Corporation has launched its matrix-assisted laser desorption/ionization time of flight (MALDI-TOF/TOF) Neoflex Imaging Profiler for mass spectrometry-based tissue imaging. Bruker unveiled the new system at the 72nd American Society of Mass Spectrometry (ASMS) meeting in Anaheim, CA.
The Neoflex multiomics mass spectrometry imaging (MSI) system was created to fill the unmet need of moving from discovery imaging to translational and clinical tissue research, Bruker noted in a statement. It comes standard with Bruker's proprietary 10-kHz smartbeam 3D laser and enhanced imaging detectors and enables OME-TIFF file output via its new SCiLS Scope software. Furthermore, the Neoflex MALDI-TOF/TOF MSI system has a benchtop-sized footprint.
In addition to MALDI HiPLEX-IHC MSI immunohistochemistry, Neoflex is also compatible with the MALDI-ISH (in situ hybridization) approach, which was announced at ASMS 2024 by AmberGen. The MALDI-ISH method multiplexes imaging of up to 12 oligomers (RNA/DNA) for multiomic spatial tissue research in neuroscience, infectious disease, and oncology.
Neoflex is also available as a TOF/TOF configuration with a reimagined fragmentation module that Bruker says significantly improves TOF/TOF sensitivity, speed, and sequence coverage. The Neoflex is compatible with Bruker's MALDI Imaging software and consumables, including IntelliSlides and SCiLS autopilot.
